SharpBetz
NFL

Detroit Lions vs Arizona Cardinals

Sunday, October 11, 2026

Final Score Lions 45 - Cardinals 21
Spread: Total:

Matchup Analysis

This NFL matchup features Detroit Lions (2-2 (2-0)) traveling to take on Arizona Cardinals (1-3 (0-1)) at State Farm Stadium, Glendale, AZ. Lions has been the stronger squad by the numbers, posting a 5.5-point per game advantage in scoring margin over Cardinals. Whether that edge translates to a cover depends on the market's pricing.

Cardinals averages 21.8 points per game, but they face a Lions defense that holds opponents to 31.8 PPG. The visitors' defensive prowess could limit the home team's scoring output. On the other side, Lions's 29.8 PPG offense should find opportunities against a Cardinals defense allowing 29.2 PPG. The visitors won't be shut down easily.

Home field advantage is worth approximately 2.0 points in NFL, and Cardinals will look to leverage their home crowd. The projected margin of 4.2 points in favor of Lions reflects a meaningful but not overwhelming advantage. The 68% confidence interval ranges from Cardinals losing by 0 to losing by 0. Both teams play in a high-scoring environment, combining for an average of 28 PPG. Shootout-caliber games tend to produce more variance, which can benefit underdogs against the spread.

The market and our model are in agreement on this matchup, which means the sharpest value won't come from the spread. Instead, examine the total and moneyline for any slight mispricing worth targeting.

Team Comparison

DET Lions
Stat
ARI Cardinals
2-2 (2-0)
Record
1-3 (0-1)
29.8
PPG
21.8
31.8
Opp PPG
29.2

Current Odds

Team Moneyline Spread Total
DET Detroit Lions
-245 ↑ -4.5 ↑ O 55.5
ARI Arizona Cardinals
+200 ↓ +4.5 ↓ U 55.5
Source: Draft Kings Updated: Oct 12, 1:20 AM
Opening line: +5.5 / O/U 54.5

Model Projection

Team Moneyline Spread Total
DET Detroit Lions
-167 -4.2 O 56.2
ARI Arizona Cardinals
+167 +4.2 U 56.2
Source: Model Updated: Oct 11, 11:30 AM

Our Picks

Spread
Pass
Model: 4.2 | Edge below threshold
Total
Pass
Model: 56.2 | Edge below threshold

Key Matchup Factors

Key Matchup Factors:

  • Lions has a +5.5 scoring margin edge
  • Home field advantage adds 2.0 points for Cardinals
  • Lions has a stronger overall record (1-3 (0-1) vs 2-2 (2-0))
  • Expected scoring: Cardinals ~27, Lions ~30 (total ~56)

Recent Trends

Cardinals's 1-3 (0-1) record tells the story of a team that has faced significant challenges this year. However, home games offer a reset. They've lost 3 straight, raising concerns about their confidence and execution heading into this one.

Lions sits at 2-2 (2-0) on the season. They've been competitive in most outings but have had their share of inconsistent performances.

In this head-to-head, execution will be paramount. The team that takes care of the football and wins the turnover battle will put itself in the best position to come out on top.

Matchup Edges

Cardinals

Advantages

  • Home field advantage worth 2.0 points in our model
  • Net scoring margin of -7.5 PPG per game
  • Win probability of 37% per model projection

Disadvantages

  • Sub-.500 record at 1-3 (0-1) (25% win rate)
  • Defense allows 29.2 PPG -- a vulnerability opponents exploit
  • On a 3-game losing streak -- confidence is fragile

Lions

Advantages

  • Potent offense averaging 29.8 PPG
  • Net scoring margin of -2.0 PPG per game
  • Model-projected win probability of 63%

Disadvantages

  • Playing on the road, sacrificing 2.0 point of home field advantage
  • Defense allows 31.8 PPG -- exploitable on the road
  • Averaging 31.8 PPG allowed on defense

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